Article
Investigations of the genomic region that contains the clf1 mutation, a causal gene in multifactorial cleft lip and palate in mice.
Birth defects research. Part A, Clinical and molecular teratology - 1 Feb 2005
Juriloff Diana M, Harris Muriel J, Dewell Sarah L, Brown Carolyn J, Mager Dixie L, Gagnier Liane, Mah Diana G
Abstract excerpt
BACKGROUND: Human nonsyndromic cleft lip and palate, CL(P), is genetically complex, with one contributing gene on chromosome 17q. A potentially homologous gene, clf1 on distal chromosome 11, is part of the digenic cause of the 10-30% CL(P) in the A/WySn mouse strain. Here we report our progress toward identifying the clf1 mutation. METHODS: Transcription from all of the known and predicted genes in the 1.5-Mb...
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