Article
Cortical acetylcholine esterase activity and ApoE4-genotype in Alzheimer disease.
Neuroscience letters - 6 Nov 2006
Eggers Carsten, Herholz Karl, Kalbe Elke, Heiss Wolf-Dieter
Abstract excerpt
Positron emission tomography (PET) studies have demonstrated reduced acetylcholine esterase (AChE) activity as an indicator of cholinergic impairment, which is a main pathogenic process in Alzheimer's disease (AD). The E4 allele of apolipoprotein epsilon (ApoE4) is a major risk factor for AD. We examined the relation between ApoE-genotype and cortical AChE activity. In 19 patients (mean age 64) with mild to...
Topics
- Acetylcholinesterase
- Aged
- Alzheimer Disease
- Apolipoprotein E4
- Cerebral Cortex
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Neuropsychological Tests