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The yeast protein Ure2p triggers Tau pathology in a mouse model of tauopathy

31 Oct 2023

Abstract excerpt

The molecular mechanisms that trigger Tau aggregation in Alzheimer's disease (AD) remain elusive. Fungi, especially Saccharomyces cerevisiae (S. cerevisiae), can be found in brain samples from patients with AD. Here, we show that the yeast protein Ure2p from S. cerevisiae interacts with Tau and facilitates its aggregation. The Ure2p-seeded Tau fibrils are more potent in seeding Tau and causing neurotoxicity in...

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PMID: 37897723
DOI: 10.1016/j.celrep.2023.113342

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