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Article

The existence of Aβ strains and their potential for driving phenotypic heterogeneity in Alzheimer's disease.

Acta neuropathologica - 1 Jul 2021

Lau Heather H C, Ingelsson Martin, Watts Joel C

Abstract excerpt

Reminiscent of the human prion diseases, there is considerable clinical and pathological variability in Alzheimer's disease, the most common human neurodegenerative condition. As in prion disorders, protein misfolding and aggregation is a hallmark feature of Alzheimer's disease, where the initiating event is thought to be the self-assembly of Aβ peptide into aggregates that deposit in the central nervous system....

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Identifiers

PMID: 32743745
DOI: 10.1007/s00401-020-02201-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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