Article
Utilising the left-helical conformation of L-DNA for analysing different marker types on a single universal microarray platform.
Nucleic acids research - 1 Jan 2006
Hauser Nicole C, Martinez Rafael, Jacob Anette, Rupp Steffen, Hoheisel Jörg D, Matysiak Stefan
Abstract excerpt
L-DNA is the perfect mirror-image form of the naturally occurring d-conformation of DNA. Therefore, L-DNA duplexes have the same physical characteristics in terms of solubility, duplex stability and selectivity as D-DNA but form a left-helical double-helix. Because of its chiral difference, L-DNA does not bind to its naturally occurring D-DNA counterpart, however. We analysed some of the properties that are...
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