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Article

Influence of lysosomal acid lipase polymorphisms on chromosome 10 on the risk of Alzheimer's disease and cholesterol metabolism.

Neuroscience letters - 24 Jul 2006

von Trotha K-T, Heun R, Schmitz S, Lütjohann D, Maier W, Kölsch H

Abstract excerpt

Linkage analyses have identified a possible hot spot for a late-onset Alzheimer's disease (LOAD) risk gene on chromosome 10q21-22 and 10q25. It was also shown that cholesterol metabolism is involved in the pathogenic mechanisms of AD. The gene of lysosomal acid lipase (LIPA) is located next to the putative hot spot on chromosome 10. Its protein is involved in cholesterol metabolism and responsible for catalysing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16730122
DOI: 10.1016/j.neulet.2006.04.009

Genes

LIPA

Provenance

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Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influence of lysosomal acid lipase polymorphisms on chromosome 10 on the risk of Alzheimer's disease and cholesterol metabolism.PMID 16730122Read ↗

Association analysis of genes involved in cholesterol metabolism located within the linkage region on chromosome 10 and Alzheimer's disease.Semantic proximity Read ↗

Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzheimer's disease in the Finnish population.Semantic proximity Read ↗

Coronary Artery Disease-Associated LIPA Coding Variant rs1051338 Reduces Lysosomal Acid Lipase Levels and Activity in Lysosomes.Semantic proximity Read ↗

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No association between SNP rs498055 on chromosome 10 and late-onset Alzheimer disease in multiple datasets.Semantic proximity Read ↗

Analysis of the disease risk locus DXS1047 polymorphism in Brazilian Alzheimer patients.Semantic proximity Read ↗

No association of lipase C polymorphisms with Alzheimer's disease.Semantic proximity Read ↗

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Lipoprotein lipase mutations and Alzheimer's disease.Semantic proximity Read ↗

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