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Article

The 8.1 ancestral MHC haplotype is associated with delayed onset of colonization in cystic fibrosis.

International immunology - 1 Nov 2006

Laki Judit, Laki István, Németh Krisztina, Ujhelyi Rita, Bede Olga, Endreffy Emoke, Bolbás Katalin, Gyurkovits Kálmán, Csiszér Eszter, Sólyom Eniko, Dobra Gergely, Halász Adrienn, Pozsonyi Eva, Rajczy Katalin, Prohászka Zoltán, Fekete György, Füst George

Abstract excerpt

Major cause of death in patients with cystic fibrosis (CF) is colonization with Staphylococcus aureus and Pseudomonas aeruginosa. The wide phenotypic variation in CF patients suggests that genes other than the cystic fibrosis transmembrane conductance regulator (CFTR) gene modify the disease. The 8.1 ancestral haplotype (8.1AH) in main histocompatibility complex is associated with alterations of the immune...

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Source

Identifiers

PMID: 16987934
DOI: 10.1093/intimm/dxl091

Genes

AGER
CFTR
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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