Article
Allotypes of alpha 1-antitrypsin in patients with cystic fibrosis, homozygous and heterozygous for deltaF508.
Pediatric pulmonology - 1 Jul 1994
Döring G, Krogh-Johansen H, Weidinger S, Høiby N
Abstract excerpt
In cystic fibrosis (CF) neutrophil released serine proteinase activity may facilitate Pseudomonas aeruginosa lung colonization, leading to chronic infection. Since such activity is mostly controlled by alpha 1-antitrypsin (alpha 1-AT), we postulated that with CF carrying deficient alpha 1-AT variants might be at higher risk for P. aeruginosa acquisition and might reveal other phenomena, specific for serine...
Topics
- Adolescent
- Adult
- Age of Onset
- Child
- Child, Preschool
- Chronic Disease
- Cystic Fibrosis
- Heterozygote
- Homozygote
- Humans
- Immunoglobulin G
- Mutation