Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Behavioral abnormalities precede neuropathological markers in rats transgenic for Huntington's disease

19 Sept 2006

Abstract excerpt

Huntington's disease (HD) is caused by an expanded CAG repeat leading to the synthesis of an aberrant protein and to the formation of polyglutamine (polyQ)-containing inclusions and aggregates. Limited information is available concerning the association of neuropathological markers with the development of behavioral markers in HD. Using a previously generated transgenic rat model of HD (tgHD rat), we performed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Neurodegenerative Diseases
Share to Neurological disorders and treatments
Share to Neurotransmitter Receptor Influence on Behavior

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16984963
DOI: 10.1093/hmg/ddl394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Behavioral abnormalities precede neuropathological markers in rats transgenic for Huntington's diseasePMID 16984963Read ↗

A Novel BACHD Transgenic Rat Exhibits Characteristic Neuropathological Features of Huntington DiseaseSemantic proximity Read ↗

Cognitive impairments in a mouse model for Huntington’s disease correlate with presymptomatic locomotion and number of CAG repeatsSemantic proximity Read ↗

Cellular and subcellular localization of Huntington aggregates in the brain of a rat transgenic for Huntington diseaseSemantic proximity Read ↗

Temporal Phenotypic Changes in Huntington's Disease Models for Preclinical Studies.Semantic proximity Read ↗

Neuronal aggregates are associated with phenotypic onset in the R6/2 Huntington's disease transgenic mouse.Semantic proximity Read ↗

Behavioral dysregulation and monoaminergic deficits precede memory impairments in human tau-overexpressing (htau) miceSemantic proximity Read ↗

Assessment of motor function, sensory motor gating and recognition memory in a novel BACHD transgenic rat model for huntington disease.Semantic proximity Read ↗

Early alterations of motor learning and corticostriatal network activity in a Huntington’s disease mouse modelSemantic proximity Read ↗

Subcellular Localization And Formation Of Huntingtin Aggregates Correlates With Symptom Onset And Progression In A Huntington’S Disease ModelSemantic proximity Read ↗

Comparative analysis of pathology and behavioural phenotypes in mouse models of Huntington's disease.Semantic proximity Read ↗

Enhanced Hippocampal Spare Capacity in Q175DN Mice Despite Elevated mHTT AggregationSemantic proximity Read ↗

Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.