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Article

Identification of NanE as the thioesterase for polyether chain release in nanchangmycin biosynthesis.

Chemistry & biology - 1 Sept 2006

Liu Tiangang, You Delin, Valenzano Chiara, Sun Yuhui, Li Jialiang, Yu Qing, Zhou Xiufen, Cane David E, Deng Zixin

Abstract excerpt

The polyketide synthase (PKS) for the biosynthesis of the polyether nanchangmycin lacks an apparent thioesterase comparable to the type I thioesterase domains of the modular PKSs responsible for macrolide biosynthesis. Three candidate polyether chain-releasing factors were examined. Both the putative CR domain and the NanE protein appeared to be genetically relevant. Among the three heterologously expressed...

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PMID: 16984884
DOI: 10.1016/j.chembiol.2006.07.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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