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Article

Analysis of the tetronomycin gene cluster: insights into the biosynthesis of a polyether tetronate antibiotic.

Chembiochem : a European journal of chemical biology - 5 May 2008

Demydchuk Yuliya, Sun Yuhui, Hong Hui, Staunton James, Spencer Jonathan B, Leadlay Peter F

Abstract excerpt

The biosynthetic gene cluster for tetronomycin (TMN), a polyether ionophoric antibiotic that contains four different types of ring, including the distinctive tetronic acid moiety, has been cloned from Streptomyces sp. NRRL11266. The sequenced tmn locus (113 234 bp) contains six modular polyketide synthase (PKS) genes and a further 27 open-reading frames. Based on sequence comparison to related biosynthetic gene...

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PMID: 18404760
DOI: 10.1002/cbic.200700715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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