Article
Emergence of drug resistance is associated with an increased risk of death among patients first starting HAART.
PLoS medicine - 1 Sept 2006
Hogg Robert S, Bangsberg David R, Lima Viviane D, Alexander Chris, Bonner Simon, Yip Benita, Wood Evan, Dong Winnie W Y, Montaner Julio S G, Harrigan P Richard
Abstract excerpt
BACKGROUND: The impact of the emergence of drug-resistance mutations on mortality is not well characterized in antiretroviral-naïve patients first starting highly active antiretroviral therapy (HAART). Patients may be able to sustain immunologic function with resistant virus, and there is limited evidence that reduced sensitivity to antiretrovirals leads to rapid disease progression or death. We undertook the...
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