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Article

Incidence of HIV-1 drug resistance among antiretroviral treatment-naive individuals starting modern therapy combinations.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Jan 2012

von Wyl Viktor, Yerly Sabine, Böni Jürg, Shah Cyril, Cellerai Cristina, Klimkait Thomas, Battegay Manuel, Bernasconi Enos, Cavassini Matthias, Furrer Hansjakob, Hirschel Bernard, Vernazza Pietro L, Ledergerber Bruno, Günthard Huldrych F

Abstract excerpt

BACKGROUND: Estimates of drug resistance incidence to modern first-line combination antiretroviral therapies against human immunodeficiency virus (HIV) type 1 are complicated by limited availability of genotypic drug resistance tests (GRTs) and uncertain timing of resistance emergence. METHODS: Five first-line combinations were studied (all paired with lamivudine or emtricitabine): efavirenz (EFV) plus zidovudine...

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PMID: 22057700
DOI: 10.1093/cid/cir728

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