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Therapeutic Drug Monitoring of Psychotropics as a Diagnostic Tool for CYP2D6 Poor Metabolizer Phenotype.

Therapeutic drug monitoring - 1 Oct 2021

Ganesh Soraya V, Beunk Lianne, Nikolik Bojan, van der Weide Jan, Bet Pierre M

Abstract excerpt

BACKGROUND: Interpatient variability in cytochrome P450 2D6 (CYP2D6) enzyme activity alters the serum concentrations of most psychotropics, which often have narrow therapeutic indices. Therefore, preemptive knowledge of CYP2D6 activity is desired. However, accessible indicators for deficient CYP2D6 activity are necessary because genotyping all patients prescribed CYP2D6 metabolized drugs is often not feasible or...

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PMID: 33560096
DOI: 10.1097/FTD.0000000000000868

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