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Article

Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study.

Reproductive biology and endocrinology : RB&E - 8 Mar 2010

Sunnotel Olaf, Hiripi Laszlo, Lagan Kevin, McDaid Jennifer R, De León Johanny M, Miyagawa Yasushi, Crowe Hannah, Kaluskar Soniya, Ward Michael, Scullion Catherine, Campbell Alan, Downes C S, Hirst David, Barton David, Mocanu Edgar, Tsujimura Akira, Cox Marc B, Robson Tracy, Walsh Colum P

Abstract excerpt

BACKGROUND: Male infertility is a common cause of reproductive failure in humans. In mice, targeted deletions of the genes coding for FKBP6 or FKBP52, members of the FK506 binding protein family, can result in male infertility. In the case of FKBP52, this reflects an important role in potentiatin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 20210997
DOI: 10.1186/1477-7827-8-22
PMCID: PMC2844388

Genes

FKBPL
FKBP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20210997-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study.PMID 20210997Read ↗

A novel mutation in FK506 binding protein-like (FKBPL) causes male infertility.Semantic proximity Read ↗

Physiological role for the cochaperone FKBP52 in androgen receptor signaling.Semantic proximity Read ↗

Identification of potentially damaging amino acid substitutions leading to human male infertility.Semantic proximity Read ↗

Is a genetic defect in Fkbp6 a common cause of azoospermia in humans?Semantic proximity Read ↗

Studies of a co-chaperone of the androgen receptor, FKBP52, as candidate for hypospadias.Semantic proximity Read ↗

Fkbp52 regulates androgen receptor transactivation activity and male urethra morphogenesis.Semantic proximity Read ↗

A homozygous FANCM frameshift pathogenic variant causes male infertility.Semantic proximity Read ↗

Bi-allelic truncating variants in CFAP206 cause male infertility in human and mouseSemantic proximity Read ↗

Genetically engineered mouse models of FK506‐binding protein 5Semantic proximity Read ↗

Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men.Semantic proximity Read ↗

The role of FKBP5 in cancer aetiology and chemoresistanceSemantic proximity Read ↗

FKBP51-Hsp90 Interaction-Deficient Mice Exhibit Altered Endocrine Stress Response and Sex Differences Under High-Fat DietSemantic proximity Read ↗

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