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Article

Induction of A.T to G.C mutations by erroneous repair of depurinated DNA following estrogen treatment of the mammary gland of ACI rats.

The Journal of steroid biochemistry and molecular biology - 1 Nov 2006

Mailander Paula C, Meza Jane L, Higginbotham Sheila, Chakravarti Dhrubajyoti

Abstract excerpt

Evidence suggests that the genotoxic mechanism of estrogens (estrone/estradiol) in breast cancer involves their oxidation to 3,4-quinones and reaction with DNA to form depurinating N3Ade and N7Gua adducts. We examined whether estrogen genotoxicity is mutagenic in the mammary gland of the female ACI rat, a model for estrogen-dependent breast cancer. Mutagenesis was studied by PCR amplification of the H-ras1 gene...

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Source

Identifiers

PMID: 16982187
DOI: 10.1016/j.jsbmb.2006.06.019

Genes

TDG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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