Article
Genotoxic metabolites of estradiol in breast: potential mechanism of estradiol induced carcinogenesis.
The Journal of steroid biochemistry and molecular biology - 1 Sept 2003
Yue W, Santen R J, Wang J-P, Li Y, Verderame M F, Bocchinfuso W P, Korach K S, Devanesan P, Todorovic R, Rogan E G, Cavalieri E L
Abstract excerpt
Long term exposure to estradiol increases the risk of breast cancer in a variety of animal species, as well as in women. The mechanisms responsible for this effect have not been firmly established. The prevailing theory proposes that estrogens increase the rate of cell proliferation by stimulating estrogen receptor-mediated transcription and thereby the number of errors occurring during DNA replication. An...
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