Preferential induction of guanine deletion at 5'-GGGA-3' in rat mammary glands by 2-amino- 1-methyl-6-phenylimidazo[4,5-b]pyridine.

doi:10.1093/carcin/20.10.1933

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Article

Preferential induction of guanine deletion at 5'-GGGA-3' in rat mammary glands by 2-amino- 1-methyl-6-phenylimidazo[4,5-b]pyridine.

Carcinogenesis - 1 Oct 1999

Okochi E, Watanabe N, Shimada Y, Takahashi S, Wakazono K, Shirai T, Sugimura T, Nagao M, Ushijima T

Abstract excerpt

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is known to induce a characteristic mutation, G deletion at the 5'-GGGA-3' site, preferentially in the lacI transgene of the colonic mucosa of Big Blue((R)) rats (BBR) and mice and specifically in the Apc gene of rat colon tumors. In this study, lacI mutations of the mammary glands in PhIP-treated rats were investigated. Six-week-old female...

Topics

Animals
Base Sequence
DNA
Female
Guanine
Imidazoles
Mammary Glands, Animal
Mice
Mutagens
Mutation
Rats
Rats, Inbred F344
Rats, Sprague-Dawley
Sequence Deletion

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Identifiers

PMID: 10506107
DOI: 10.1093/carcin/20.10.1933

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