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Article

Mechanism of the highly efficient quenching of tryptophan fluorescence in human gammaD-crystallin.

Biochemistry - 26 Sept 2006

Chen Jiejin, Flaugh Shannon L, Callis Patrik R, King Jonathan

Abstract excerpt

Quenching of the fluorescence of buried tryptophans (Trps) is an important reporter of protein conformation. Human gammaD-crystallin (HgammaD-Crys) is a very stable eye lens protein that must remain soluble and folded throughout the human lifetime. Aggregation of non-native or covalently damaged HgammaD-Crys is associated with the prevalent eye disease mature-onset cataract. HgammaD-Crys has two homologous...

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Identifiers

PMID: 16981715
DOI: 10.1021/bi060988v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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