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Article

The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification

5 Apr 2019

Abstract excerpt

Peg10 (paternally expressed gene 10) is an imprinted gene that is essential for placental development. It is thought to derive from a Ty3-gyspy LTR (long terminal repeat) retrotransposon and retains Gag and Pol-like domains. Here we show that the Gag domain of PEG10 can promote vesicle budding similar to the HIV p24 Gag protein. Expressed in a subset of mouse endocrine organs in addition to the placenta, PEG10...

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PMID: 30951545
DOI: 10.1371/journal.pone.0214110

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