Article
KRAS variation and risk of endometriosis.
Molecular human reproduction - 1 Nov 2006
Zhao Zhen Zhen, Nyholt Dale R, Le Lien, Martin Nicholas G, James Michael R, Treloar Susan A, Montgomery Grant W
Abstract excerpt
Endometriosis is a common gynaecological disease with symptoms of pelvic pain and infertility which affects 7-10% of women in their reproductive years. Activation of an oncogenic allele of Kirsten rat sarcoma viral oncogene homologue (KRAS) in the reproductive tract of mice resulted in the development of endometriosis. We hypothesized that variation in KRAS may influence risk of endometriosis in humans. Thirty...
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