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Article

APOBEC mediated mutagenesis drives genomic heterogeneity in endometriosis.

Journal of human genetics - 1 Jun 2022

Revathidevi Sundaramoorthy, Nakaoka Hirofumi, Suda Kazuaki, Fujito Naoko, Munirajan Arasambattu Kannan, Yoshihara Kosuke, Enomoto Takayuki, Inoue Ituro

Abstract excerpt

Endometriosis is a benign gynecologic condition, acting as a precursor of certain histological subtypes of ovarian cancers. The epithelial cells of endometriotic tissues and normal uterine endometrium accumulated somatic mutations in cancer-associated genes such as phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) and Kirsten rat sarcoma (KRAS) proto-oncogene. To determine the...

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Identifiers

PMID: 35017684
DOI: 10.1038/s10038-021-01003-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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