Article
A polymorphism in a let-7 microRNA binding site of KRAS in women with endometriosis.
EMBO molecular medicine - 1 Mar 2012
Grechukhina Olga, Petracco Rafaella, Popkhadze Shota, Massasa Efi, Paranjape Trupti, Chan Elcie, Flores Idhaliz, Weidhaas Joanne B, Taylor Hugh S
Abstract excerpt
Endometriosis is found in 5-15% of women of reproductive age and is more frequent in relatives of women with the disease. Activation of KRAS results in de novo endometriosis in mice, however, activating KRAS mutations have not been identified in women. We screened 150 women with endometriosis for a polymorphism in a let-7 microRNA (miRNA) binding site in the 3'-UTR of KRAS and detected a KRAS variant allele in...
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