Article
Biological significance of KRAS mutant allele expression in ovarian endometriosis.
Cancer science - 1 May 2021
Yachida Nozomi, Yoshihara Kosuke, Suda Kazuaki, Nakaoka Hirofumi, Ueda Haruka, Sugino Kentaro, Yamaguchi Manako, Mori Yutaro, Yamawaki Kaoru, Tamura Ryo, Ishiguro Tatsuya, Kase Hiroaki, Motoyama Teiichi, Enomoto Takayuki
Abstract excerpt
KRAS is the most frequently mutated in ovarian endometriosis. However, it is unclear whether the KRAS mutant allele's mRNA is expressed and plays a biological role in ovarian endometriosis. Here, we performed mutation-specific RNA in situ hybridization to evaluate mutant allele expression of KRAS p.G12V, the most frequently detected mutation in ovarian endometriosis in our previous study, in formalin-fixed...
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