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The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependent

15 Feb 2012

Abstract excerpt

Aurora kinases are mitotic serine/threonine protein kinases and are attractive novel targets for anticancer therapy. Many small-molecule inhibitors of Aurora kinases are currently undergoing clinical trials. Aurora A kinase is essential for successful mitotic transition. MK8745 is a novel and selective small-molecule inhibitor of Aurora A kinase. MK8745 induced apoptotic cell death in a p53-dependent manner when...

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PMID: 22293494
DOI: 10.4161/cc.11.4.19323

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