Article
A novel mutation detection approach of hMLH1 and hMSH2 genes for screening of colorectal cancer.
Cancer detection and prevention - 1 Jan 2006
Yuan Ziqiang, Legendre Benjamin, Sreeramoju Prashanth, Lowes Christina, Reynolds Davis, Bennett Anna, Kent Tara Sotsky, Miller Agnes, Zhu Jim, Weber Thomas K
Abstract excerpt
BACKGROUND: Recently, Denaturing High-Performance Liquid Chromatography (DHPLC) has been widely used for mutation detection hMLH1 and hMSH2 genes due to reduced cost of analysis, accuracy, and high sample throughput. Unfortunately, one major drawback in screening the hMLH1 and hMSH2 genes with any analysis technique involves sample preparation. Additionally, there are limitations to this technique which include:...
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