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Article

Accurate, high-throughput "snapshot" detection of hMLH1 mutations by two-dimensional DNA electrophoresis.

Genetic testing - 1 Jan 1998

Smith W M, Van Orsouw N J, Fox E A, Kolodner R D, Vijg J, Eng C

Abstract excerpt

The human genome and related projects have resulted in the isolation of a rapidly growing number of genes that cause susceptibility to human cancer. With rare exception, these genes are large and have disease-associated mutations scattered along the length of the genes. Therefore, the development of accurate and cost-efficient mutation detection tests that can scan entire genes singly or in combination is...

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Share to Adaptor Proteins, Signal Transducing
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis, Gel, Two-Dimensional

Share to Heteroduplex Analysis

Share to MutL Protein Homolog 1

Share to Neoplasm Proteins

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Source

Identifiers

PMID: 10464596
DOI: 10.1089/gte.1998.2.43

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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