Article
Polymorphisms in pfcrt, pfmdr1, dhfr genes and in vitro responses to antimalarials in Plasmodium falciparum isolates from Bangui, Central African Republic.
The American journal of tropical medicine and hygiene - 1 Sept 2006
Menard Didier, Yapou Ferdinand, Manirakiza Alexandre, Djalle Djibrine, Matsika-Claquin Marcelle Diane, Talarmin Antoine
Abstract excerpt
Drug resistance is probably the greatest challenge to most malaria-control programs. Given the limited resources for other malarial-control measures, rational drug used is crucial. Molecular markers for parasite resistance such as pfcrt, pfmdr-1, and dhfr have the potential to be used in an integ...
Topics
- Animals
- Antimalarials
- Central African Republic
- In Vitro Techniques
- Membrane Proteins
- Membrane Transport Proteins
- Multidrug Resistance-Associated Proteins
- Mutation
- Plasmodium falciparum
- Polymorphism, Genetic
- Protozoan Proteins
- Tetrahydrofolate Dehydrogenase