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Article

Polymorphisms in pfcrt, pfmdr1, dhfr genes and in vitro responses to antimalarials in Plasmodium falciparum isolates from Bangui, Central African Republic.

The American journal of tropical medicine and hygiene - 1 Sept 2006

Menard Didier, Yapou Ferdinand, Manirakiza Alexandre, Djalle Djibrine, Matsika-Claquin Marcelle Diane, Talarmin Antoine

Abstract excerpt

Drug resistance is probably the greatest challenge to most malaria-control programs. Given the limited resources for other malarial-control measures, rational drug used is crucial. Molecular markers for parasite resistance such as pfcrt, pfmdr-1, and dhfr have the potential to be used in an integrated fashion to provide timely information that is useful to policy makers. Therefore, we evaluated polymorphisms in...

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PMID: 16968910

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