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Article

Comparison between instrumental variable and mediation-based methods for reconstructing causal gene networks in yeast.

Molecular omics - 1 Apr 2021

Ludl Adriaan-Alexander, Michoel Tom

Abstract excerpt

Causal gene networks model the flow of information within a cell. Reconstructing causal networks from omics data is challenging because correlation does not imply causation. When genomics and transcriptomics data from a segregating population are combined, genomic variants can be used to orient the direction of causality between gene expression traits. Instrumental variable methods use a local expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33438713
DOI: 10.1039/d0mo00140f

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