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Article

Ex-vivo analysis of CD8+ T cells infiltrating colorectal tumors identifies a major effector-memory subset with low perforin content.

Journal of clinical immunology - 1 Sept 2006

Ye Sheng-Wei, Wang Yu, Valmori Danila, Ayyoub Maha, Han Yan, Xu Xiao-Lan, Zhao Ai-Lian, Qu Li, Gnjatic Sacha, Ritter Gerd, Old Lloyd J, Gu Jin

Abstract excerpt

Previous studies have indicated that the infiltration of CD8+ T cells in colorectal cancer is an independent predictor of increased survival but clinical observations have suggested that the cytotoxic function of CD8+ T cells infiltrating colorectal cancer may often be limited. In this study, we have assessed the phenotype of colorectal cancer CD8+ tumor-infiltrating lymphocytes (TILs) isolated ex vivo from tumor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16967323
DOI: 10.1007/s10875-006-9040-4

Genes

CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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