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Article

Lack of association between IL-12B gene polymorphism and autoimmune thyroid disease in Japanese patients.

Endocrine journal - 1 Dec 2004

Ikeda Yukio, Yoshida Wakako, Noguchi Toru, Asaba Koichi, Nishioka Tatsuya, Takao Toshihiro, Hashimoto Kozo

Abstract excerpt

Interleukin (IL)-12 is a key factor in cell-mediated immunity that drives the development of Th1 cells and stimulates T lymphocytes and natural killer cells to produce interferon (INF)-gamma. The IL-12B gene, which encodes the p40 subunit of IL-12, is located at chromosome 5q31-33 and a linkage finding for autoimmune thyroid disease (AITD) on 5q31-33 in a Japanese population has been reported. It is also reported...

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PMID: 15644581
DOI: 10.1507/endocrj.51.609

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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