Article
Lack of association of interleukin-18 gene polymorphisms with susceptibility of Japanese populations to Graves' disease or Graves' ophthalmopathy.
Thyroid : official journal of the American Thyroid Association - 1 Mar 2006
Mukai Tokunori, Hiromatsu Yuji, Ichimura Michiko, Fukutani Tomoka, Kaku Hiroo, Miyake Ikuyo, Shoji Shingo, Koda Yoshiro, Bednarczuk Tomasz
Abstract excerpt
OBJECTIVE: To investigate whether polymorphisms of interleukin (IL)-18 gene confer susceptibility to Graves' disease (GD) and Graves' ophthalmopathy (GO). DESIGN: We performed a case control study on polymorphisms of IL-18 gene in Japanese patients with GD (n = 435), and healthy control subjects without antithyroid autoantibodies or family history of autoimmune disorders (n = 255). The C-4675G, C-607A, and G-137C...
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