Article
Granulocyte macrophage--colony-stimulating factor (GM-CSF) decreases CD1a expression by human Langerhans cells and increases proliferation in the mixed epidermal cell-lymphocyte reaction (MELR).
The Journal of investigative dermatology - 1 Sept 1990
Kolenik S, Ding T G, Longley J
Abstract excerpt
Langerhans cells (LC) undergo a variety of phenotypic and functional changes in vitro. To determine the effects of granulocyte macrophage--colony-stimulating factor (GM-CSF), tumor necrosis factor-alpha (TNF-alpha), and interleukin 1-alpha (IL-1) on LC phenotype in vitro, epidermal cell suspensio...
Topics
- Antigens, CD1
- Antigens, Differentiation
- Biological Factors
- Cell Division
- Colony-Stimulating Factors
- Cytokines
- Granulocyte-Macrophage Colony-Stimulating Factor
- Growth Substances
- Humans
- Langerhans Cells
- Lymphocyte Activation
- Lymphocyte Culture Test, Mixed
- Phenotype
- T-Lymphocytes