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Article

Rescue of degradation-prone mutants of the FK506-rapamycin binding (FRB) protein with chemical ligands.

Chembiochem : a European journal of chemical biology - 9 Jul 2007

Stankunas Kryn, Bayle J Henri, Havranek James J, Wandless Thomas J, Baker David, Crabtree Gerald R, Gestwicki Jason E

Abstract excerpt

We recently reported that certain mutations in the FK506-rapamycin binding (FRB) domain disrupt its stability in vitro and in vivo (Stankunas et al. Mol. Cell, 2003, 12, 1615). To determine the precise residues that cause instability, we calculated the folding free energy (Delta G) of a collectio...

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PMID: 17525916
DOI: 10.1002/cbic.200700087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17525916-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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