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Article

Cytochrome P450 2D6 phenotype predicts antidepressant efficacy of venlafaxine: a secondary analysis of 4 studies in major depressive disorder.

The Journal of clinical psychiatry - 1 Nov 2010

Lobello Kasia W, Preskorn Sheldon H, Guico-Pabia Christine J, Jiang Qin, Paul Jeffrey, Nichols Alice I, Patroneva Albena, Ninan Philip T

Abstract excerpt

INTRODUCTION: Venlafaxine, a serotonin-norepinephrine reuptake inhibitor antidepressant, is metabolized primarily by the cytochrome P450 2D6 enzyme into O-desmethylvenlafaxine (ODV). The ODV/venlafaxine ratio can be used to distinguish between extensive metabolizers (EMs) and poor metabolizers (PMs). OBJECTIVES: To determine the relative efficacy and tolerability of venlafaxine in EM vs PM patients with major...

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Identifiers

PMID: 20441720
DOI: 10.4088/JCP.08m04773blu

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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