Article
Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2007
Philibert Robert, Madan Anup, Andersen Allan, Cadoret Remi, Packer Hans, Sandhu Harinder
Abstract excerpt
The serotonin reuptake transporter (5HTT) is thought to be the principal regulator of serotonergic activity and epigenetic effects at this locus are thought to be important moderators of vulnerability to neuropsychiatric illness. In attempt to understand the basis of this regulation, several gene...
Topics
- Base Sequence
- Cell Line
- CpG Islands
- DNA Methylation
- DNA, Complementary
- Epigenesis, Genetic
- Exons
- Genetics, Behavioral
- Genotype
- Humans
- Molecular Sequence Data
- Promoter Regions, Genetic
- RNA, Messenger
- Serotonin Plasma Membrane Transport Proteins