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Article

Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2007

Philibert Robert, Madan Anup, Andersen Allan, Cadoret Remi, Packer Hans, Sandhu Harinder

Abstract excerpt

The serotonin reuptake transporter (5HTT) is thought to be the principal regulator of serotonergic activity and epigenetic effects at this locus are thought to be important moderators of vulnerability to neuropsychiatric illness. In attempt to understand the basis of this regulation, several gene polymorphisms that affect 5HTT mRNA levels have been described. But to date, no clear mechanism linking these...

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PMID: 16958039
DOI: 10.1002/ajmg.b.30414

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