Article
Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region.
Science (New York, N.Y.) - 29 Nov 1996
Lesch K P, Bengel D, Heils A, Sabol S Z, Greenberg B D, Petri S, Benjamin J, Müller C R, Hamer D H, Murphy D L
Abstract excerpt
Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated in anxiety in humans and animal models and is the site of action of widely used uptake-inhibiting antidepressant and antianxiety drugs. Human 5-HT transporter (5-HTT) gene transcription is modulated by a...
Topics
- Adolescent
- Adult
- Alleles
- Anxiety Disorders
- Carrier Proteins
- Cell Line
- Female
- Genetic Markers
- Genotype
- Humans
- Male
- Membrane Glycoproteins
- Membrane Transport Proteins
- Middle Aged
- Nerve Tissue Proteins
- Neurotic Disorders