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Article

Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region.

Science (New York, N.Y.) - 29 Nov 1996

Lesch K P, Bengel D, Heils A, Sabol S Z, Greenberg B D, Petri S, Benjamin J, Müller C R, Hamer D H, Murphy D L

Abstract excerpt

Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated in anxiety in humans and animal models and is the site of action of widely used uptake-inhibiting antidepressant and antianxiety drugs. Human 5-HT transporter (5-HTT) gene transcription is modulated by a common polymorphism in its upstream regulatory region. The short variant of the polymorphism reduces the...

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Identifiers

PMID: 8929413
DOI: 10.1126/science.274.5292.1527

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region.PMID 8929413Read ↗

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Association of the 5-HTT gene-linked promoter region (5-HTTLPR) polymorphism with psychiatric disorders: review of psychopathology and pharmacotherapySemantic proximity Read ↗

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