Article
Relationship of serotonin transporter gene polymorphisms and haplotypes to mRNA transcription.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jul 2005
Bradley Sarah L, Dodelzon Katerina, Sandhu Harinder K, Philibert Robert A
Abstract excerpt
The serotonin transporter (5HTT; chromosomal location 17q12) is an important regulator of serotonergic neurotransmission and is the site of action for a number of antidepressant medications. Sequence variation at a VNTR known as the 5HTTLPR, which is 1.4 kb upstream of the translation start of 5H...
Topics
- Analysis of Variance
- Cell Line
- Genotype
- Haplotypes
- Humans
- Membrane Glycoproteins
- Membrane Transport Proteins
- Minisatellite Repeats
- Nerve Tissue Proteins
- Polymorphism, Single Nucleotide
- RNA, Messenger
- Serotonin Plasma Membrane Transport Proteins
- Transcription, Genetic