Article
The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jul 2008
Philibert Robert A, Sandhu Harinder, Hollenbeck Nancy, Gunter Tracy, Adams William, Madan Anup
Abstract excerpt
Serotonin Transporter (5HTT or SLC6A4) mRNA transcription is regulated by both genetic and epigenetic mechanisms. Unfortunately, despite intense scrutiny, the exact identity and contribution of each of these regulatory mechanisms, and their relationship to behavioral illness remain unknown. This lack of knowledge is critical because alterations in SLC6A4 function are posited to be central to a wide variety of CNS...
Topics
- Adult
- Alcoholism
- Base Sequence
- Cell Line, Transformed
- DNA Methylation
- Depressive Disorder, Major
- Epigenesis, Genetic
- Female
- Genetic Predisposition to Disease