Article
Similarity of the allele frequency and linkage disequilibrium pattern of single nucleotide polymorphisms in drug-related gene loci between Thai and northern East Asian populations: implications for tagging SNP selection in Thais.
Journal of human genetics - 1 Jan 2006
Mahasirimongkol Surakameth, Chantratita Wasun, Promso Somying, Pasomsab Ekawat, Jinawath Natini, Jongjaroenprasert Wallaya, Lulitanond Viraphong, Krittayapoositpot Phanida, Tongsima Sissades, Sawanpanyalert Pathom, Kamatani Naoyuki, Nakamura Yusuke, Sura Thanyachai
Abstract excerpt
The similarity of the marker allele frequency and linkage disequilibrium structure between two populations are major factors for the determination of the transferability and efficiency of haplotype tagging SNP derived from one population to use for an indirect association study in another population. To prove the similarity between northern East Asian populations in Hapmap and Thais, 861 SNP in 166 drug-related...
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