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Article

Influence of an LRP5 cytoplasmic SNP on Wnt signaling and osteoblastic differentiation.

Bone - 1 Jan 2007

Guo J, Cooper L F

Abstract excerpt

The low density lipoprotein receptor-related protein 5 (LRP5) is a key determinant of bone mass, via the Wnt signaling pathway control of osteoblast function. This study examined human LRP5 signaling and the effects of an intracellular domain single nucleotide polymorphism (SNP: p.V1525A) on osteoblast differentiation and mineralization. Constitutively active LRP5 was constructed by deletion of the extracellular...

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Source

Identifiers

PMID: 16956801
DOI: 10.1016/j.bone.2006.07.016

Genes

LRP5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Influence of an LRP5 cytoplasmic SNP on Wnt signaling and osteoblastic differentiation.PMID 16956801Read ↗

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