Article
Golgi vesiculation and lysosome dispersion in cells lacking cytoplasmic dynein.
The Journal of cell biology - 6 Apr 1998
Harada A, Takei Y, Kanai Y, Tanaka Y, Nonaka S, Hirokawa N
Abstract excerpt
Cytoplasmic dynein, a minus end-directed, microtubule-based motor protein, is thought to drive the movement of membranous organelles and chromosomes. It is a massive complex that consists of multiple polypeptides. Among these polypeptides, the cytoplasmic dynein heavy chain (cDHC) constitutes the major part of this complex. To elucidate the function of cytoplasmic dynein, we have produced mice lacking cDHC by...
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