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Article

Optimization of antibody binding by adjusting thermodynamic stability during the maturation of antibody affinities.

Protein science : a publication of the Protein Society - 1 Sept 2026

Akazawa-Ogawa Yoko, Matsuda Tomonari, Kiyose Norihiko, Miyazaki Nobuo, Fukuta Tetsuo, Adachi Motoyasu, Ito Yuji, Hagihara Yoshihisa

Abstract excerpt

Somatic mutations and antibody clone selection occur in B-cell hyper-evolution over extremely brief periods of time. Herein, we developed a technique for antibody screening by immunizing alpacas with antigens and observing antibody sequence transitions over time, a method we named Tracking the Evolution of Antibodies over time. This technique allows the observation of sequence transitions of somatic mutations in...

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Identifiers

PMID: 42559765
DOI: 10.1002/pro.70739
PMCID: PMC13445567

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