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Article

Disruption of orbitofrontal cortex laterality in offspring from multiplex alcohol dependence families.

Biological psychiatry - 15 Jan 2009

Hill Shirley Y, Wang Shuhui, Kostelnik Bryan, Carter Howard, Holmes Brian, McDermott Michael, Zezza Nicholas, Stiffler Scott, Keshavan Matcheri S

Abstract excerpt

BACKGROUND: Increased susceptibility for developing alcohol dependence (AD) might be related to structural differences in brain circuits that influence the salience of rewards and/or modify the efficiency of information processing. The role of the orbitofrontal cortex (OFC) in regulating emotional processing is increasingly being recognized along with its association with impulsive behavior. METHODS: Magnetic...

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Identifiers

PMID: 18986649
DOI: 10.1016/j.biopsych.2008.09.001
PMCID: PMC3280899

Genes

BDNF
HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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