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Transcriptional Genomics Associates FOX Transcription Factors With Human Heart Failure

4 Sept 2006

Abstract excerpt

BACKGROUND: Specific transcription factors (TFs) modulate cardiac gene expression in murine models of heart failure, but their relevance in human subjects remains untested. We developed and applied a computational approach called transcriptional genomics to test the hypothesis that a discrete set of cardiac TFs is associated with human heart failure. METHODS AND RESULTS: RNA isolates from failing (n=196) and...

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PMID: 16952980
DOI: 10.1161/circulationaha.106.632430

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