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PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis

21 Apr 2024

Abstract excerpt

Much effort has been made to uncover the cellular heterogeneities of human hearts by single-nucleus RNA sequencing. However, the cardiac transcriptional regulation networks have not been systematically described because of the limitations in detecting transcription factors. In this study, we optimized a pipeline for isolating nuclei and conducting single-nucleus RNA sequencing targeted to detect a higher number...

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PMID: 38644381
DOI: 10.1038/s41392-024-01804-5

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