Article
Human collagen II peptide 256-271 preferentially binds to HLA-DR molecules associated with susceptibility to rheumatoid arthritis.
Immunogenetics - 1 Jan 1999
Diab B Y, Lambert N C, L'Faqihi F E, Loubet-Lescoulié P, de Préval C, Coppin H
Abstract excerpt
The binding ability of 23 overlapping peptides, all derived from the CB11 fragment of CII, was tested on several HLA-DR molecules associated or not with disease susceptibility. These experiments were performed on a variety of cells expressing different HLA-DR molecules, using both indirect and di...
Topics
- Amino Acid Sequence
- Animals
- Arthritis, Rheumatoid
- Autoimmune Diseases
- Binding Sites
- Binding, Competitive
- Collagen
- Genetic Predisposition to Disease
- HLA-DR Antigens
- Humans
- Immunodominant Epitopes
- Mice
- Molecular Sequence Data
- Peptide Fragments
- Protein Binding
- Structure-Activity Relationship