Article
Human collagen II peptide 256-271 preferentially binds to HLA-DR molecules associated with susceptibility to rheumatoid arthritis.
Immunogenetics - 1 Jan 1999
Diab B Y, Lambert N C, L'Faqihi F E, Loubet-Lescoulié P, de Préval C, Coppin H
Abstract excerpt
The binding ability of 23 overlapping peptides, all derived from the CB11 fragment of CII, was tested on several HLA-DR molecules associated or not with disease susceptibility. These experiments were performed on a variety of cells expressing different HLA-DR molecules, using both indirect and direct binding assays. The CII (256-271) fragment was shown to bind to a restricted population among which the HLA-DR...
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