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Article

Identification of four novel mutations in the HNF-1A gene in Chinese early-onset and/or multiplex diabetes pedigrees.

Chinese medical journal - 5 Jul 2006

Yang Zhen, Wu Song-hua, Zheng Tai-shan, Lu Hui-juan, Xiang Kun-san

Abstract excerpt

BACKGROUND: Mutations in the hepatocyte nuclear factor-1A gene cause the type 3 form of maturity-onset diabetes of the young (MODY3). This study was undertaken to determine mutations and sequence variations of the HNF-1A gene in Chinese with familial early-onset and/or multiplex diabetes mellitus. METHODS: We screened all ten exons of the HNF-1A gene, including exon/intron junctions, by direct sequencing in 272...

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PMID: 16834925

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