Article
Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese population.
Diabetes - 1 Apr 2009
Wang Congrong, Hu Cheng, Zhang Rong, Bao Yuqian, Ma Xiaojing, Lu Jingyi, Qin Wen, Shao Xinyu, Lu Junxi, Xu Jing, Lu Huijuan, Xiang Kunsan, Jia Weiping
Abstract excerpt
OBJECTIVE: Hepatocyte nuclear factor 1beta (HNF1beta) is a transcription factor that is critical for pancreatic cell formation and glucose homeostasis. Previous studies have reported that common variants of HNF1beta were associated with type 2 diabetes in Caucasians and West Africans. However, analysis in the subjects from the Botnia study and Malmö Preventive Project produced conflicting results, and the role...
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