Article
A link in transcription between the native pbpB and the acquired mecA gene in a strain of Staphylococcus aureus.
Microbiology (Reading, England) - 1 Sept 2006
Gardete Susana, de Lencastre Hermínia, Tomasz Alexander
Abstract excerpt
Conditional mutants of pbpB with an IPTG-inducible promoter were used to compare the effects of interrupted transcription of this gene in a meticillin-sensitive (MSSA) and a meticillin-resistant (MRSA) strain of Staphylococcus aureus. After 3 h growth following the removal of IPTG, multiplication of the MSSA strain stopped abruptly, cells began to lyse, and membrane preparations showed greatly decreased...
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